This Awesome Product Can Help To Slow The Aging Process
Alpha Lipoic Acid is an amazing product. It really acts as an antioxidant enhancer. By doing this it reduces oxidation at the cell level. This oxidation from free radicals can greatly increase the body’s aging and make you more susceptible to cancer and many other diseases plus it does a terrific job regulating blood sugar. The problem with health food store alpha lipoic acid is that it breaks down and is eliminated from the body in around 30 minutes. Plus it usually is in a form that can’t be used by the body, it usually contains harmful additives, and it’s made in China. This wasn't acceptable to me. In conjunction with a top FDA approved research facility Health Masters has developed a sustained release of Alpha Lipoic Acid which I feel is the best in the world. Plus, I have the research to prove it. I have included a brief overview of the research that was done to develop this product at the bottom of this post. As with all Health Masters products, it is the best! If I can’t find what I want, I have it developed.
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This is very expensive research but what it has provided to you the consumer and my friends is the finest highest quality with today’s scientific knowledge. I feel blessed to be able to provide this product to you. Please read the following overview, call my office with any questions that you may have, and get your supply today! Again, this product helps antioxidant vitamins work much better, it helps slow the aging process as well as assisting to regulate blood sugar levels. Personally, I take one capsule morning and evening each day.
To sum up the research, Health Masters Sustained Release Alpha Lipoic Acid is a multifunctional antioxidant that helps to keep your cells healthy. It neutralizes free radicals at the moment of their formation before they can damage cells. This product has the ability to destroy free radical in both water and fat based cells making it an ideal whole body antioxidant. Plus, it increases the body’s production of glutathione (our bodies own whole body antioxidant and detoxifier) by a full 30%. Health Masters Sustained Release Alpha Lipoic Acid also regenerates vitamins C, E and CoQ10 giving them the ability to continue fighting free radicals for an extended period of time. Again, Health Masters Sustained Release Alpha Lipoic Acid is a patented controlled release product so you are protected all day! Plus, I even add biotin to help support our Alpha Lipoic Acid in regulating sugar metabolism.
Defend Yourself Against 100,000 Attacks A Day with Health Masters Sustained Release Patented
Alpha Lipoic Acid!
Normal metabolism, disease and aging produce by-products in all of your cells. These are highly-reactive molecules we call "free radicals". Inside your body they are capable of damaging proteins, fats and even DNA, the genetic building material for every cell. The main source of free radical production is the cell's mitochondria, the "powerhouse" where energy is produced. The body produces approximately 2.2 pounds of free radicals in a year! He says this is enough for about 100,000 "attacks" on the DNA each cell's mitochondria each day!
The degree of free radical damage depends upon age; the older you are, the more damage. Fortunately, the body has an arsenal of antioxidants to use against free radicals; the most potent being Health Masters Sustained Release Patented Alpha Lipoic Acid. My wife and I take this product daily. Health Masters Sustained Release Patented Alpha Lipoic Acid is both water-soluble like vitamin C and fat soluble, like vitamin E. Its solubility in fat is especially important because that makes our sustained release patented Alpha Lipoic Acid a very effective protector of cell membranes which are made up of fatty acids. Likewise, its solubility in water is an important characteristic because that lets Lipoic Acid combat free radicals in the watery compartment in cells. So you can see that Health Masters Sustained Release Alpha Lipoic Acid is even better than vitamin C or vitamin E; in addition it has the ability to boost up tissue levels of these two antioxidants vitamins, CoQ10, another antioxidant; and also help the body manufacture glutathione, yet another very powerful antioxidant.
Free radical damage (also called, "oxidative stress") is believed to play a role in diabetes, including perhaps even its very beginnings and later its complications. It is also thought to be one of the culprits of hardening of the arteries. Oral supplementation of Health Masters Sustained Release Patented Alpha Lipoic Acid has been shown to improve the body's use of insulin (thus lowering blood sugar) in people with Type 2 Diabetes. (Free Radic.Biol.Med. 27:309-314) Diabetics, pay attention!
As the years go by, the mitochondria in your cells don't function as well as they may have when you were young and this leads to more free radicals; unfortunately, your antioxidant system's capacity also weakens. Research data supports the notion that supplementing with Lipoic Acid can do double-duty for you! First, it may counteract the decline in the cell's ability to produce energy which results in production of less free radicals. Second, Health Masters Sustained Release Patented Alpha Lipoic Acid, will be able to counteract the increased free radical damage that comes with aging. If you keep the level of Lipoic Acid in the tissues significantly high over an extended period of time which is key to reaping the greatest benefits.
Until now you could only buy Alpha Lipoic Acid in a form that stayed in your bloodstream for only about 30 minutes before half of it disappeared. Let's face it, who has time, or would even want to take a supplement every half hour or so? If you haven't heard about Alpha Lipoic Acid before, this may be the reason. It was hard to make it work effectively due to this dosing problem.
I recently introduced Health Masters Sustained Release Patented Alpha Lipoic Acid, a controlled-release form of Alpha Lipoic Acid that delivers tiny amounts to the tissues over an extended period of time so that the best levels can be achieved and maintained. I am so excited to now be able to offer you this controlled-released form that is so special it holds four patents!
Whereas regular Alpha Lipoic Acid stays in your bloodstream for only about 30 minutes; Health Masters Sustained Release Patented Alpha Lipoic Acid stays in the blood stream for several hours!
One molecule of Health Masters Sustained Release Patented Alpha Lipoic Acid can cancel out the effect of 1000 free radicals!!!!!
Health Masters Sustained Release Patented Alpha Lipoic Acid
- Increases your cell's master "de-toxifier" glutathione level by 30%!
- Regenerates the vitamins C and E, and CoQ10 you consume, increasing the time they are available to combat free radicals!
- Helps your whole body use glucose for more effective energy production! Consider it stimulant-free energy support!
- Will help support healthy blood sugar levels, even if you have diabetes.
- Is well-tolerated and has a very good safety record!
Health Masters Alpha Lipoic Acid
Health Masters Alpha Lipoic Acid, a potent oxidative stress antagonist, is a proprietary, orally active, controlled-release formulation of racemic alpha lipoic acid (containing both R and S-enantiomers) that has a pharmacokinetic advantage over other alpha lipoic acid formulas. Other brands are rapidly cleared from the plasma within about 30 minute; whereas, Health Masters Alpha Lipoic Acid remains in the plasma for several hours. In other words this product stays in your blood stream for hours helping and feeding your cells. Other brands don’t.
Quick Facts: Health Masters Alpha Lipoic Acid
- Neutralizes Oxygen Radicals, Ionized Metals and a Variety of Other Free Radicals
- Coenzyme for Whole Body Glucose Utilization
- Increases Intracellular Glutathione Levels Reduced by Aging, Diseases, Moderate/
- Strenuous Exercise
- Reduces Oxidative Stress that Leads to Diabetic Neuropathy
- Regenerates Vitamins C&E and Maintains Balance between Oxidized & Reduced CoQ10
Health Masters Controlled Release Lipoic Acid
PRODUCT SUMMARY
Health Masters’ Controlled-Release α-Lipoic Acid Alpha Lipoic Acid™ is a proprietary, patented, orally active, controlled-release formulation of racemic α-lipoic acid. α-Lipoic acid is a disulfide compound that is produced in trace quantities in cells, where it functions naturally as a coenzyme . These enzymes are important for oxidative glucose metabolism. α-Lipoic acid functions as a multi-functional antioxidant. Supplementation with α-lipoic acid provides a number of beneficial physiological effects:
Principal among these are improvements in the markers of oxidative stress such as increased tissue glutathione levels, reduced levels of lipid peroxides, and other markers of oxidative stress. This is significant because oxidative stress is associated with neurodegenerative diseases such as neuropathy.
Regeneration of the endogenous antioxidant network (helps to maintain vitamins C and E).
Several clinical studies point to the beneficial effect a-lipoic acid has on diabetics and on sugar metabolism. (23,24)
Alpha Lipoic Acid is also an ideal antioxidant to counteract the increased levels of free radicals generated during moderate to strenuous exercise. You need this product to help prevent tissue damage when and after you work out.
The primary advantage of the Health Masters formulation is that it increases the length of time in plasma of a-lipoic acid (several hours). This provides our product with an advantage that is a marked improvement over other a-lipoic acid products in which a-lipoic acid is rapidly eliminated from the body usually within 30 minutes (2). Controlled-release technology is what makes our Alpha Lipoic Acid appropriate for use as a potent oxidative stress antagonist. Oxidative stress, and specifically its imbalance with antioxidant depletion, is associated neuropathy.
Controlled-release technology is also what improves our alpha lipoic acid in helping to control blood sugar levels. Data from a 12-week clinical study in patients with type 2 diabetes indicate that supplementation with Alpha Lipoic Acid (1200 mg per day, divided doses as add-on therapy with other anti-hyperglycemic medications) demonstrated a number of benefits including a significant reduction of plasma sugar, along with a trend towards reduced C-peptide (3). The ability of a-lipoic acid to improve glycemic control when administered in a controlled-release formulation has never been reported previously with commercially available non-controlled release a-lipoic products. In addition, many subjects in the study exhibited a marked increase in insulin sensitivity (judged by a reduction in C-peptide). It helps to maintain good blood sugar levels. Whether taken alone, or in combination with other high blood sugar medications, Alpha Lipoic Acid is well tolerated and does not produce alterations in liver or kidney function.
Health Masters sustained release Alpha Lipoic Acid, in summary, represents a scientifically developed and clinically tested dietary supplement for use as a multi-functional antioxidant to counteract free radical formation and to help promote healthy blood sugar levels. Most notably, Alpha Lipoic Acid helps to reduce oxidative stress that has been linked to neuropathy.
PRODUCT DESCRIPTION
Health Masters Alpha Lipoic Acid is a controlled-release formulation of racemic a-lipoic acid. a-Lipoic acid is a disulfide compound that is produced in trace quantities in cells, where it functions naturally as a coenzyme in the pyruvate dehydrogenase and a-ketoglutarate dehydrogenase mitochondrial enzyme complexes. In effective doses, a-lipoic acid functions as a multifunctional antioxidant.
The primary advantage of the Health Masters Alpha Lipoic Acid formulation is that it increases the length of time effective concentrations of a-lipoic acid are present in plasma over time (several hours) (2). This provides our Alpha Lipoic Acid with a marked improvement over other a-lipoic acid products in which a-lipoic acid is rapidly cleared in 30 minutes. Alpha Lipoic Acid represents a scientifically developed and clinically tested dietary supplement appropriate for use by individuals who are more susceptible to oxidative stress. Alpha Lipoic Acid is an aid to enhance blood sugar metabolism. It is also for use as a multi-functional antioxidant in healthy individuals to counteract the increase in free radical formation during exercise.
INDICATIONS AND USAGE
Alpha Lipoic Acid antagonizes oxidative stress and facilitates whole-body glucose utilization. In healthy individuals, Alpha Lipoic Acid is indicated for the routine maintenance and enhancement of tissue and whole-body , through its controlled-release technology, has exhibited positive effects on promoting health.
In other conditions associated with high levels of oxidative stress, Alpha Lipoic Acid may also be used as an approach to counteract the deterioration of mitochondrial function that occurs with aging.
Oxidative Stress And Neuropathy
Neuropathy has been causally linked to oxidative stress. There is considerable evidence to indicate that oxidative stress plays an important role in the etiology of diabetic complications. Many of the biochemical pathways (e.g. protein glycation, polyol pathway, and glucose oxidation) associated with hyperglycemia can result in increased free radical production.
Enhancing Blood Sugar Control
Alpha Lipoic Acid is an appropriate adjunctive approach to enhance blood sugar control. a-Lipoic acid has been shown, through IV, to significantly increase insulin sensitivity in type 2 diabetics (as judged by % change in metabolic clearance rate). In contrast, oral administration of non-controlled-release tablets exerts a minimal effect on insulin sensitivity. (1) (See chart on next page).
Similarly, a-lipoic acid has exhibited positive effects on insulin sensitivity. Data from a 12-week clinical study in patients with type 2 diabetes indicate that supplementation with a-lipoic acid (1200 mg per day, divided doses as add-on therapy with other anti-hyperglycemic medications) demonstrated a number of benefits including a significant reduction of plasma fructosamine, along with a trend toward reduced C-peptide. (3)
In another study, subjects were given 1000 mg of a-lipoic acid daily. Metabolic clearance rate (MCR) increased 55% (p<0.05) and insulin sensitivity increased 57% (p<0.05). (1) Subsequently, the same group reported that dosages of 500 mg per day, for 10 days, enhanced MCR and insulin sensitivity by 30% (p<0.05).
Adverse Reactions
To date, a-lipoic acid in daily doses of 600-1800 mg have been well-tolerated.. In humans, possible moderate hypoglycemia in diabetic patients, as a consequence of improved glucose utilization with very high doses (>2000 mg per day). This dose is well above the dose recommended by Health Masters for Alpha Lipoic Acid (see below). Nevertheless, those with diabetes and problems with glucose intolerance should monitor their blood glucose and adjust their anti-diabetic medication, if necessary, to avoid possible hypoglycemia.
OVERDOSAGE
There are no reports of α-lipoic acid overdosage.
CLINICAL SAFETY
In studies sponsored by Health Masters, Alpha Lipoic Acid was evaluated (oral administration) at doses of 600, 900, and 1200 mg. At these doses, Alpha Lipoic Acid was well tolerated with no significant treatment-related adverse events (see below and (3)). Studies to date have reported no significant side effects with the administration of a-lipoic acid.
Alpha Lipoic Acid CLINICAL TRIALS
Pharmacokinetics
Safety, Tolerability, Efficacy
Health Masters has evaluated the tolerability of Alpha Lipoic Acid in humans. An IRB-approved study of the effects of Alpha Lipoic Acid on type 2 diabetics has been completed. Patients received 12 weeks of active treatment (900 mg/day for 6 weeks and 1200 mg/day for 6 weeks), and were monitored on a regular basis for glucose and lipid control, liver enzymes, along with other clinical markers. In this study, there were no significant side effects reported. Importantly, there were no significant changes in liver enzymes, or liver or kidney function (3). With regard to efficacy, a clinically beneficial effect (p < 0.05) with regard to the reduction of plasma fructosamine, an intermediate-term (~3-week) indicator of glucose control, was reported. In addition to the reduction in plasma fructosamine, a reduction in glycated hemoglobin (HbA1c) in about 50% of the subjects was observed. In this open-label study, all subjects remained on their existing anti-hyperglycemic medications; Alpha Lipoic Acid was administered in combination with these other medications.
Alpha Lipoic Acid MANUFACTURING
Health Masters purchases the highest purity of a-lipoic acid available, and manufactures under the equivalent of US FDA current Good Manufacturing Practices (cGMPs). Health Masters has devoted extensive resources to develop a controlled-release formulation of a-lipoic acid. Alpha Lipoic Acid is the first and only commercially available controlled-release formulation of a-lipoic acid that has been evaluated clinically. It took well over 100 different formulations and experiments to achieve the steady state plasma levels resulting in therapeutic efficacy.
Alpha Lipoic Acid FORMULATION
The formulation of Alpha Lipoic Acid is designed to deliver α-lipoic acid in a controlled manner over a period of about 2-3 hours (3). The make-up of the formulation is proprietary and 4 US patents have been awarded.
DOSAGE AND ADMINISTRATION
As is the case with many supplemental regimes, dosing management should be individualized. For example, to protect against free radical accumulation, to improve tissue and whole-body antioxidant status, and to improve mitochondrial function, healthy individuals should take Alpha Lipoic Acid daily, one tablet before breakfast and one tablet before dinner.
In individuals where free radical production is above normal, it is suggested to take two tablets before breakfast and one tablet before dinner.
In all cases, it is highly recommended to take Alpha Lipoic Acid 30-60 minutes before eating, as absorption of a-lipoic acid might be affected (i.e. reduced) by food or delayed gastric emptying (21,22).
References
1. Evans JL, Goldfine ID: a-Lipoic acid: a multi-functional antioxidant that improves insulin sensitivity in patients with type 2 diabetes.. Diabetes Technol Therap 2:401-413, 2000
2. Teichert J, Kern J, Tritschler HJ, Ulrich H, Preiss R: Investigations on the pharmacokinetics of alpha-lipoic acid in healthy volunteers. Int.J.Clin.Pharmacol.Ther. 36:625-628, 1998
3. Evans JL, Heymann CJ, Goldfine ID, Gavin LA: Pharmacokinetics, tolerability, and fructosamine-lowering effect of a novel, controlled release formulation of a-lipoic acid. Endocr Pract 8:29-35, 2002
4. alpha-Lipoic acid. Altern.Med.Rev. 3:308-310, 1998
5. Gleiter CH, Schreeb KH, Freudenthaler S, Thomas M, Elze M, Fieger-Buschges H, Potthast H, Schneider E, Schug BS, Blume HH, Hermann R: Lack of interaction between thioctic acid, glibenclamide and acarbose. Br.J..Clin.Pharmacol. 48:819-825, 1999
6. Ziegler D, Reljanovic M, Mehnert H, Gries FA: Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials. Exp Clin Endocrinol Diabetes 107:421-430, 1999
7. Jacob S, Ruus P, Hermann R, Tritschler HJ, Maerker E, Renn W, Augustin HJ, Dietze GJ, Rett K: Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type 2 diabetes mellitus: a placebo-controlled pilot trial. Free Radic Biol Med 27:309-314, 1999
8. Biewenga GP, Haenen GR, Bast A: The pharmacology of the antioxidant lipoic acid. Gen Pharmacol 29:315-331, 1997
9. Lewis RL, Sweet DV: Registry of Toxic Effects of Chemical Substances 1983-1984. Cincinnati, US Health and Human Services, 1985
10. Packer L, Witt EH, Tritschler HJ: alpha-Lipoic acid as a biological antioxidant. Free Radic Biol Med 19:227-250, 1995
11. Evans JL, Goldfine ID, Maddux BA, Grodsky GM: Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 23:599-622, 2002
12. Packer L: alpha-Lipoic acid: a metabolic antioxidant which regulates NF-kappa B signal transduction and protects against oxidative injury. | Drug Metab Rev 30:245-275, 1998
13. Hofmann MA, Schiekofer S, Isermann B, Kanitz M, Henkels M, Joswig M, Treusch A, Morcos M, Weiss T, Borcea V, Abdel Khalek AK, Amiral J, Tritschler H, Ritz E, Wahl P, Ziegler R, Bierhaus A, Nawroth PP: Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB. Diabetologia 42:222-232, 1999
14. Sen CK: Redox signaling and the emerging therapeutic potential of thiol antioxidants. Biochem.Pharmacol. 55:1747-1758, 1998
15. Jacob S, Henriksen EJ, Schiemann AL, Simon I, Clancy DE, Tritschler HJ, Jung WI, Augustin HJ, Dietze GJ: Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Arzneimittel-Forschung 45:872-874, 1995
16. Jacob S, Henriksen EJ, Tritschler HJ, Augustin HJ, Dietze GJ: Improvement of insulin-stimulated glucose-disposal in type 2 diabetes after repeated parenteral administration of thioctic acid. Exp Clin Endocrinol Diabetes 104:284-288, 1996
17. Konrad T, Vicini P, Kusterer K, Hoflich A, Assadkhani A, Bohles HJ, Sewell A, Tritschler HJ, Cobelli C, Usadel KH: Alpha-lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes. Diabetes Care 22:280-287, 1999
18. Saltiel AR, Olefsky JM: Thiazolidinediones in the treatment of insulin resistance and type II diabetes. Diabetes 45:1661-1669, 1996
19. Evans JL, Goldfine ID, Maddux BA, Grodsky GM: Are oxidative stress-activated signaling pathways mediators of insulin resistance and b-cell dysfunction? Diabetes 52:1-8, 2003
20. Maddux BA, See W, Lawrence JC, Jr., Goldfine AL, Goldfine ID, Evans JL: Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by micromolar concentrations of a-lipoic acid. Diabetes 50:404-410, 2001
21. Gleiter CH, Schug BS, Hermann R, Elze M, Blume HH, Gundert-Remy U: Influence of food intake on the bioavailability of thioctic acid enantiomers. Eur.J.Clin.Pharmacol. 50:513-514, 1996
22. Hermann R, Wildgrube HJ, Ruus P, Niebch G, Nowak H, Gleiter CH: Gastric emptying in patients with insulin dependent diabetes mellitus and bioavailability of thioctic acid-enantiomers. Eur.J.Pharm.Sci. 6:27-37, 1998
23. DeFronzo RA, Tobin JD, Andres R: Glucose clap technique: A method for quantifying insulin secretion and resistance. Am J Physiol 1979;237:E214-E223.
24. Ferrannini E, Mari A: How to measure insulin sensitivity. J Hypertension 1998;6:895-906.
25. Shigeta Y, Hiraizumi G, Wada M, Oji K, Yoshida T: Study on the serum level of thioctic acid in patients with various diseases. J Vitaminol 7:48-52, 1961
Sincerely,
Dr Ted Broer
