Can Aleve, Advil and Ibuprofen KILL YOU? The Truth EXPOSED!
Submitted by Dr. Ted Broer on Thu, 11/22/2012 - 14:37
Finally, Guaranteed Products That Manage Pain and Rebuild Joint Cartilage
Dear Friends,
There are so many side effects associated with these drugs including itching skin that I avoid them. We have an excellent program using three different products to control so many problems. Good old fashioned Health Masters’ all natural, super high potency, Organic Fermented Cod Liver Oil, combined with our Joint Rebuilding Formula and Proprietary Herbal Joint Relief Formula are amazing for getting rid of aches and pains. I am in my 50’s. I don’t go a day without using them and the results are incredible!
Before I share with you about this amazing trilogy of natural pain relief products (below) it is imperative for you to understand from a technical perspective the terrible side effects found in many of the over-the-counter pain medicines that are probably in your medicine cabinet!
What are COX2 (COX-2) Inhibitors and How do They Work?
To understand COX-2 (COX2) Inhibitors, you first have to understand COX-1 (COX1) and what its role in the body is. Regular NSAIDS (generally COX-1 and COX-2 Inhibitors) work by inhibiting the production of prostaglandins (PGs). Prostaglandins are fatty-acid derivatives located all over your body that are well known for their inflammation and immune response effects. However, they also have many different roles in the body. A scientific list would read as such: PG’s are involved in as diverse normal processes as ovulation, blood clotting, renal function, wound healing, vasomotor tone, platelet aggregation, differentiation of immune cells, nerve growth, bone metabolism, and initiation of labor. Pretty essential to your body, wouldn’t you say?
If you are familiar with the fact that when you are using drugs such as aspirin, your blood thins and you bruise easier, that is a “side effect” of the COX-1 inhibitor. In the above list, that would fall under the blood clotting category. Remember, COX-1 inhibitors work by inhibiting PG’s. Due to the acidity of the stomach, the cells of your stomach are replaced very quickly, within a few days. One of the major roles of PG’s is to keep the lining of the stomach intact, and when your PG system is disrupted (say by taking COX-1 drugs like many NSAIDS) stomach irritation, digestive tract problems and even intestinal or stomach bleeding and death could occur.
COX-2 inhibitors were discovered later, as a “healthier, more targeted” way of treating the inflammation – without the side effects. This makes sense as COX-2 is found more commonly in inflammatory and immune cells than COX-1 drugs, which exist throughout the body. Unfortunately, this would prove to be far, far from the truth. While COX-2 is more specific to inflammation, the side effects can be worse than COX-1 drugs.
NSAID Side Effects
The side effects of COX-1 drugs are pretty terrible. It is estimated that 25% experience some kind of side effect and 5% develop SERIOUS health consequences such as GI (stomach) bleeding, acute renal failure, or worse.
The New England Journal of Medicine reports that “anti-inflammatory drugs (prescription and over-the-counter, which include Advil®, Motrin®, Aleve®, Ordus®, Aspirin, and over 20 others) alone cause over 16,500 deaths and over 103,000 hospitalizations per year in the US”, according to a review article published in the New England Journal of Medicine (1).
You can see why researchers would believe there was a clear cut and dry line between COX-1 and COX-2. The message was clear: research (and get patents for) drugs that actually inhibited only COX-2 and you would have a blockbuster drug on your hands. Unfortunately, like many things, it was not nearly as cut and dry as this. Over the counter drugs such as Ibuprofen and Naproxen work to inhibit COX-1 and COX-2. Aspirin works more on COX-1. Some others such as diclofenac work primarily on COX-2 but also affect COX-1. However, even “selective” COX-2 inhibitors aren’t that selective. At therapeutic dosages, they inhibit enough COX-1 to potentially cause the same stomach toxicity and other associated problems as COX-1. Not to the exact same extent but more than enough to do damage.
Remember, 16,500 people are KILLED by “harmless” and “common” NSAIDS such as aspirin or ibuprofen every year. In development are other “newer aspirins” that may prove to ACTUALLY be more selective for COX-2 than COX-1, but in the mean time – despite claims of being “selective” – the current COX-2’s such as Vioxx® (rofecoxib) or (celecoxib) are simply not selective enough, not to mention some of their potentially horrible side effects and the associated lawsuits that have been filed due to side effects such as heart attacks, stroke and blood clots2. Our advice is to explore (for osteoarthritis) other alternative, cheaper and far more effective treatments for your pain. Glucosamine is a natural (and as such not patentable by large drug companies) substance that has been shown to not just be at least as effective as Ibuprofen and other related drugs but also can slow or maybe even stop the spread of osteoarthritis. Plus, it works to rejuvenate cartilage and rebuild the damage that has already occurred. Not even a pure "second generation" COX-2 drug will be able to do that.
References: 1. Wolfe MM, et. al. NEJM 1999;340(24):1888-99
Now some GOOD GREAT News!
We have finally developed a clinically tested natural pain management product combined with a new joint product that has been clinically proven to re-grow cartilage and naturally manage pain especially when used in conjunction with our good old fashioned Health Masters’ all natural, super high potency, Organic Fermented Cod Liver Oil. Wow what a breakthrough! We have named these two products Health Masters’ Joint Rebuilding Formula and Proprietary Herbal Joint Relief Formula.
After 30 years in the nutraceutical and wellness business it has become increasingly more difficult to get me excited about new product releases. Well, guess what? This one excites me!
But, there is one thing I have got to tell you. You all know that I don't eat pork or shellfish but there are exceptions to products made from them. An example being thyroid extract from pork and insulin from pork. Both of these products have been real life savers. So when we started working on the joint product I was hesitant to use green mussel extract. In the initial research we did not want to include the extract. The problem is the results including it have been nothing short of miraculous. This product really works! So again, to me it falls into the categories of insulin and thyroid extract with the same incredible results. It is kind of like soy. I can’t stand it and won’t eat it but in some of our products the highest quality source of vitamin E is derived from soy. You know I tell you not to eat soy but the vitamin E from soy is great. That's the way the green mussel extract works. I don’t eat shellfish nor would I ever willingly do so but I do use and endorse this product.
My mother in law is 74 years young. She loves the product and what it has done for her joints. My wife Sharon is an active 52 year young mother of four. We exercise together 6 days a week and both of us have experienced joint improvement using this product. It has literally been a miracle for my wife's joints. Many of you may not know this but my wife is a black belt in Karate. She even won the weapons competition in the US open which is a world martial arts competition. Well to be blunt, she really messed up her shoulders, elbows, and wrists during her years in martial arts. Guess what? These two products have completely gotten rid of all her joint pain. Combining these products with H~G~H Stimulate has literally turned back the hands of time. She has even started doing pull-ups. The other day while watching her do pull-ups I reminded her that she was 52. She smiled and said I feel like I am 20 years old. Age is just a number. Then she continued doing more pull-ups. I must say God has really blessed me with an incredible wife. We have been married for 25 years. 24 of those years have been great. As I have written before one year was ruff when she started menopause. But after we discovered a hormone stabilization program she was back to normal. It’s exciting to me I have a wife who looks 30, works out like a teenager, is an incredible mother and wife, and who eats right and has written multiple bestselling books. Wow, I feel so blessed. Well enough of all the mushy stuff. I must tell you it was my privilege to develop a product that has fixed her joints.
So here is my commitment to you. Use these two products for 90 days as directed. If you do not have the same incredible results that Sharon, myself, my mother in law, and the clinical trial participants have experienced keep the product and I will give you a full credit in my office for the full purchase price of your order up to a three months supply. Plus, you don’t even need to return the unused portion. Since you are already getting my newsletter, I trust you. You see, I have already run the clinical trials. I know the results that you’re going to get. I can’t make a better offer than a no-risk-trial. I know that many of you want the clinical research behind these incredible products. Well here it is. I hope you enjoy reading the technical stuff. I find it very fascinating especially the part that compares it with other pain management products.
Health Masters’ Natural Health Product Line for the Management of Articular and Muscular Pain |
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Proprietary Herbal Joint Relief Formula
Relieves pain associated with arthritis and arthrosis, morning stiffness and low back pain.
Proprietary Joint Rebuilding Formula
Helps protect and develop healthy cartilage, prevents pain associated to arthrosis and improves mobility and flexibility of articulations.
Organic Fermented Cod Liver Oil
Good old fashioned Health Masters’ all natural, super high potency, Organic Fermented Cod Liver Oil.
References
1. Jang MH, et al. Harpagophytum procumbens suppresses lipopolysaccharide-stimulated expressions of cyclooxygenase-2 and inducible nitric oxide synthase in firbroblast cell line L929. J Pharmacol. Sci., 2003, 93(3): p. 367-371.
2. Loew D, et al. Investigation on the pharmacokinetic properties of Harpagophytum extracts and their effects on eicosanoid biosynthesis in vitro and ex vivo. Clin. Pharmacol. Ther., 2001. 69(5): p. 356-364.
3. Schulze-Tanzil G, et al. Effect of a Harpagophytum procumbens DC extract on matrix metalloproteinases in human chondrocytes in vitro. Arzneimittelforschung, 2004. 54(4): p.213-220
4. Litlle C, Parsons T. Herbal therapy for treating rheumatoid arthritis. Cochrane Database Syst. Rev. 2001: (1) : CD002948
5. Garbacki N, et al. Effects of prodelphinidins isolated from Ribes nigrum on chondrocyte metabolism and COX activity. Naunyn Schmiedebergs Arch Pharmacol. 2002 Jun;365(6):434-41. Epub 2002 Apr 26
6. Miller T, Wu H. In vivo evidence for prostaglandin inhibitory activity in New Zealand green-lipped mussel extract. N Z Med J. 1984 Jun 13;97(757):355-7.
7. Curtis CL, et al. Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids., Arthritis Rheum. 2002 Jun;46(6):1544-53.
8. Curtis CL, et al. n-3 fatty acids specifically modulate catabolic factors involved in articular cartilage degradation., J Biol Chem. 2000 Jan 14;275(2):721-4
9. S.L.M. Gibson and R.G. Gibson. The treatment of arthritis with a lipid extract of Perna canaliculus: a randomized trial. Complement Ther Med 1998;6:122-6.
10.. LAU CS et al. Treatment of knee osteoarthritis with Lyprinol®, lipid extract of the green-lipped mussel – a doubleblind placebo-controlled study. Progress in Nutrition 2004; 6(1):17-31.
11. Cho SH, et al. Clinical efficacy and safety of Lyprinol, a patented extract from New Zealand green-lipped mussel (Perna Canaliculus) in patients with osteoarthritis of the hip and knee: Multicenter Clinical Trial with a 2-months treatment period. The Newest Medical Journal 2002; 45(5):27-33.
12. Chrubasik S, Eisenberg E, et al. Treatment of low back pain exacerbations with willow bark extract: a randomized double-blind study. Am J Med 2000 Jul;109(1):9-14.
13. Chrubasik S, Kunzel O, et al. Treatment of low back pain with a herbal or synthetic anti-rheumatic: a randomized controlled study. Willow bark extract for low back pain. Rheumatology (Oxford). 2001 Dec;40(12):1388-93.
14. Schmid B, Ludtke R, et al. Efficacy and tolerability of a standardized willow bark extract in patients with osteoarthritis: randomized placebo-controlled, double blind clinical trial. Phytother Res 2001 Jun;15(4):344-50.
15. Fiebich BL, Chrubasik S. Effects of an ethanolic salix extract on the release of selected inflammatory mediators in vitro., Phytomedicine. 2004 Feb;11(2-3):135-8.
16. Smolinski AT, Pestka JJ. Comparative effects of the herbal constituent parthenolide (Feverfew) on lipopolysaccharide-induced inflammatory gene expression in murine spleen and liver. J Inflamm (Lond). 2005 Jun 29;2:6.
17. Calliste CA, Trouillas P, Allais DP, Simon A, Duroux JL, Free radical scavenging activities measured by electron spin resonance spectroscopy and B16 cell antiproliferative behaviors of seven plants., J Agric Food Chem. 2001 Jul;49(7):3321-7.
18. Evidence-based Systematic Review of Birch by the Natural Standard Research Collaboration. Copyright ® 2007. www.naturalstandard.coma>. Accessed 12/12/2008.
19. Peter Holmes, Birch Leaf and Bark. In: The Energetics of Western Herbs: A Materia Medica Integrating Western & Chinese Herbal Therapies. Page 705, Volume 2. Fourth edition, 2006. South Lotus Press.
Proprietary Joint Rebuilding Formula
Proprietary Joint Rebuilding Formula, a member of Health Masters’ Exclusive and Patented (”EP”) line is the result of Health Masters’ partnership with Biotanika™, a Canadian company that develops evidence-based natural health products for pain management. It is among a group of formulas that also includes Proprietary Herbal Joint Relief Formula. The formulation of Proprietary Joint Rebuilding Formula began with researchers at Biotanika investigating the potential of traditional herb extracts to act additively or synergistically to reduce inflammation and pain using the lowest doses of each herb. Biotanika used three pre-clinical test protocols that are recognized by the scientific community as good models for inflammatory diseases. These tests resulted in formulas benchmarked with current standards of care used in western medicine.
The primary goal of the first clinical trial of the two formulas was to assess the safety and efficacy for the relief of pain in fourteen patients with either low back pain, joint (knee, shoulder, or hip) pain, or muscular or articular pain (the majority had moderate-to-severe pain). These patients had visited a natural health care practitioner seeking alternative therapies to NSAIDs or surgery. As is most often seen in patients scheduled for knee replacement surgery or who have had knee replacements, benefit was nil. However, all patients with low back, hip and shoulder pain demonstrated significant benefit.
- Glucosamine Sulfate, a chondro-protective agent occurring naturally in all human tissues, appears to stimulate the manufacture of cartilage components and the deposition of sulfur into the cartilage. In combination with chondroitin sulfate it may be effective in patients with moderate-to-severe knee pain [1,2,3].
- Methylsulfonylmethane (MSM) is a naturally-occurring, sulfur-containing, water-soluble compound (AKA DMSO2) has been demonstrated to possess anti-inflammatory and antioxidant properties [4,5].
- Chondroitin Sulfate, a primary proteoglycan in the body, attracts and retains a significant quantity of water guaranteeing cartilage resistance and elasticity. It has anti-inflammatory and antioxidative properties. [7,8].
- Hyaluronic Acid, a naturally occurring glycosaminoglycan in synovial fluid, helps create a viscous environment, cushion joints and maintains normal joint function. It has anti-inflammatory and antioxidant properties [9,10]
- Vitamin C and Manganese- Vitamin C is essential for synthesis of collagen and for maintaining its integrity. Manganese is important in the growth and development of normal bone and in the synthesis of cartilage [11]. Studies in rats, rabbits and humans have demonstrated a joint supportive, anti-inflammatory effect of a combination of glucosamine, chondroitin and manganese ascorbate. [21,22].
References
1. Distler J, Anguelouch A. Evidence-based practice: review of clinical evidence on the efficacy of glucosamine and chondroitin in the treatment of osteoarthritis. J Am Acad Nurse Pract. 2006 Oct;18(10):487-93 [PMID: 16999714]
2. Clegg DO, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006 Feb 23;354(8):795-808 [PMID: 16495392]
3. Matheson AJ, Perry CM. Glucosamine: a review of its use in the management of osteoarthritis. Drugs Aging. 2003;20(14):1041-60 [PMID:14651444]
4. Parcell S. Sulfur in human nutrition and applications in medicine. Altern Med Rev. 2002 Feb;7(1):22-44 [PMID: 11896744]
5. Beilke MA, et al. Effects of dimethyl sulfoxide on the oxidative function of human neutrophils. J Lab Clin Med 1987, 110:91-96 [PMID:3598341]
7. Chan PS. Glucosamine and chondroitin sulfate regulate gene expression and synthesis of nitric oxide and prostaglandin E(2) in articular cartilage explants. Osteoarthritis Cartilage. 2005 May;13(5):387-94 [PMID: 15882562]
8. Ha BJ. Oxidative stress in ovariectomy menopause and role of chondroitin sulfate. Arch Pharm Res. 2004 Aug;27(8):867-72 [PMID: 15460450]
9. Campo GM, et al. Aromatic trap analysis of free radicals production in experimental collagen-induced arthritis in the rat: protective effect of glycosaminoglycans treatment. Free Radic Res. 2003 Mar;37(3):257-68.[PMID: 12688421]
10. Campo GM, et al. Administration of hyaluronic acid and chondroitin-4-sulfate limits endogenous antioxidant depletion and reduces cell damage in experimental acute pancreatitis. Pancreas. 2004 Mar;28(2):E45-53. [PMID: 15028960]
11. Strause L, et al.The effect of deficiencies of manganese and copper on osteoinduction and on resorption of bone particles in rats. Calcif Tissue Int. 1987 Sep;41(3):145-50. [PMID: 3117341]
12. Beren J, et al. Effect of pre-loading oral glucosamine HCl/chondroitin sulfate/manganese ascorbate combination on experimental arthritis in rats. Exp Biol Med (Maywood). 2001 Feb;226(2):144-51 [PMID:11446439]
13. Das A Jr, et al. Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis. Osteoarthritis Cartilage.
Chondrocytes: Critical Cells for the Health of our Cartilage
Chondrocytes are key cells in our cartilage. It produces and maintains the cartilage tissue, that consists essentially of collagen and proteoglycan. They are essential for the regeneration of the cartilage.
Proprietary Herbal Joint Relief Formula and Proprietary Joint Rebuilding Formula outperform glucosamine and chondroitin.
Microscopic look at the articulation with osteoarthritis (histochemical analysis of the tissues)
Inflammation is the “initiator” of many discomforts
Many preclinical studies have been performed. These studies demonstrated that the combination of Proprietary Herbal Joint Relief Formula and Proprietary Joint Rebuilding Formula modulates certain intermediates responsible for inflammation thereby reducing the swelling and associated pain.
Finally, a natural medicine line of natural health products!
- Ingredients were selected based on independent scientific research that demonstrated their safety and efficacy.
- Products tested in preclinical models used by the pharmaceutical industry.
- A rigorous quality control program: each batch of ingredients and final product is tested by an independent laboratory to assure that it conforms to specifications (purity, identity) and that it is free of contaminants or adulterants such as heavy metals, pesticides, synthetic NSAIDs. Testing program includes confirming plant part and subspecies.
- Management team consists of professionals from the pharmaceutical industry and 25 years of nutraceutical research.
- Solid experience in preclinical and clinical product development as well as regulatory affairs and natural health products.
Scientific Facts
Arthritis: a chronic degenerative disease of the articulations (cartilage); its evolution limits the mobility of the articulations and causes pain, swelling and loss of joint flexibility.
Arthrosis: is the most frequent form of arthritis; a disease associated with stress/injury to the articulations; it progresses in acute phases; often associated with age or old accidents/injuries to the articulations.
Advancements : better understanding of the mechanisms involved in the degeneration of cartilage and the development of alternative treatments that are less damaging to the GI tract.
Benefits: improvement in the quality of life such as better joint flexibility and mobility and reduced pain.
