HGH Stimulate: A Review of Ingredients
Healthmasters’ HGH Stimulate was developed with one task in mind: promoting blood and oxygen flow to peripheral tissues. As a result of that design goal, Healthmasters’ HGH Stimulate helps to maintain healthy male sexual function, support lean body mass and athletic performance, supports dilation of blood vessels and healthy blood pressure, and promotes healthy blood and oxygen flow to the brain for healthy mood, mind, and memory.
All of these benefits are derived from one point: nitric oxide (NO) production.
NO has critical roles in regulating the function of organs and systems throughout the body, and it is well-known that NO production by endothelial cells (cells lining the blood vessels) plays a critical role in blood flow regulation. Abnormal and decreased NO production can adversely affect blood flow, delivery of nutrients and oxygen, and other vascular functions.
In this article, we will examine the six ingredients in Healthmasters’ HGH Stimulate, and how they promote blood flow and NO production. *
Research has shown that homocysteine may decrease the bioavailability of NO . Accordingly, research shows that folate helps maintain healthy homocysteine levels   . Therefore, folate’s deleterious effect on homocysteine may provide the added benefit of increasing NO levels through enhancing NO bioavailability.
Additionally, folate is also involved in the body’s synthesis of tetrahydrobiopterin (THBP), and THBP is an essential cofactor for nitric oxide synthase (NOS). Inadequate levels of folate may impact the synthesis of THBP , and 5-MTHF (bioactive folate) may normalize the activity of NOS in THBP-depleted endothelial cells .
In 2007, researchers conducted a randomized, placebo-controlled study investigating the vascular effects of two different doses of folic acid (400 microg/d or 5 mg/d) against a placebo. The researchers found that the 400microg/d improved vascular function through effects on endothelial nitric oxide synthases and vascular oxidative stress .
L-arginine is a precursor to nitric oxide and has various roles, including supporting the immune response, ammonia detoxification, growth hormone secretion (during rest), improved exercise performance, wound healing, reduced platelet aggregation, and vasodilation (expansion of blood vessels)  . During times of stress, the body is not able to produce sufficient amounts, and the arteries experience endothelial dysfunction; however, supplementing with L-arginine has been shown rectify this issue
A multitude of studies have found that L-arginine supplementation was effective regarding endothelial dysfunction, cardiovascular diseases, hypertension, type-2 diabetes, arterial elasticity, oxidative stress, and erectile dysfunction [10-32].
For example, a 2006 study investigated the effects of L-arginine supplementation in asymptomatic patients. The dosage was 1,050mg twice a day. After a week, systolic blood pressure [upper measurement] was reduced in 65% of patients, with an average decrease of 4mmHg. Diastolic blood pressure [lower measurement] was reduced in 69% of patients, with an average reduction of 3.7 mmHg. In the patients who were borderline or hypertensive [high blood pressure], there was a mean systolic reduction of 11mmHg, with a 4.9 mmHg decrease of diastolic blood pressure. Researchers also noted that after one week, pulse wave analysis showed a significant increase in large artery compliance. The researchers concluded, “a moderate dose of sustained-release L-arginine can improve endothelial function and blood pressure” .
In a 2002 randomized, double-blind trial, researchers found, “Oral administration of L-arginine acutely improves endothelium-dependent, flow-mediated dilatation of the brachial artery in patients with essential hypertension,” meaning L-arginine improved blood flow .
Because of increased blood flow, there are additional benefits to L-arginine supplementation.
Because low NO levels can lead to endothelial dysfunction which can lead to erectile dysfunction, in a 1999 study, researchers found that oral L-arginine in high dose seemed to cause significant subjective improvement in sexual function in men with organic erectile dysfunction in patients who had low nitric oxide levels .
These are only three of the twenty-two cited studies that are available below [10-32].
L-citrulline is a precursor to L-arginine that quickly permeates the intestinal wall and enters the bloodstream. From there, L-citrulline is processed in the kidneys where it becomes L-arginine, and oral supplementation of L- citrulline has been shown to increase plasma L-arginine availability for NOS .
In a 2005 animal study, researchers found, “L-arginine plus L-citrulline, either alone or in combination with antioxidants [vitamin C and E which are also in this product], caused a marked improvement in endothelium-dependent vasorelaxation and blood flow, dramatic regression in atheromatous lesions, and decrease in superoxide production and oxidation-sensitive gene expression” .
Further, a 2010 human study found that the administration of L-arginine and L-citrulline had a beneficial effect on endothelial function in the treatment of heart failure .
A 2018 meta-analysis investigated the effects L-citrulline possesses regarding blood pressure and concluded, “Our results suggest that L-citrulline supplementation may reduce systolic BP. A significant reduction in diastolic BP was observed only in the studies that used doses ≥ 6 g/day” .
Additional studies have investigated L- citrulline’s effects regarding hypertension [37-40].
Quercetin is a major flavonoid naturally occurring in plants and has been shown to possess a wide array of effects. For example, quercetin promotes healthy, balanced production of NO and prevents the overexpression of inducible NOS (iNOS). Quercetin’s specific actions and mechanisms behind supporting NO production and preventing vascular inflammation are extraordinarily complex and require a rather deep-level understanding of various biological activities; however, if you would like to read about them, see references [41-43].
Its anti-oxidative stress effects have also warranted numerous investigations, and I have found nearly forty studies that show it is an extremely beneficial compound [44-81].
Vitamins C and E
Last but not least, Healthmasters’ HGH Stimulate provides vitamins C and E. Free-radical injury and oxidization reduce NO bioavailability, and antioxidants appear to preserve NO. Further, healthy endothelial function is associated with low oxidative stress, and vitamins C and E are exceptional antioxidants, as noted in recent articles [82-84].
A 2000 study found that vitamin E and C can improve NO activity , and a 2004 study found that vitamin E works with vitamin C to synergistically “provide optimal conditions for endothelial NO formation” . Finally, additional studies have found other ingredients in this product to be more effective when taken with vitamins C and E .
This is only a small view of the large amount of research that went into developing Healthmasters’ HGH Stimulate. Each ingredient was chosen explicitly because through one way or another supports the body’s production of NO, which has many positive effects, including healthy blood pressure, proper erectile function, and increased oxygen flow for athletic conditions.
If you have any questions about Healthmasters’ HGH Stimulate, please feel free to call our office at 800.726.184.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.