Joint Rebuilding Formula: A Review of Ingredients


Healthmasters’ Joint Rebuilding Formula was formulated with one thing in mind: Joint Health.

This may seem to be a given because the product has the word “joint” in its name, but a lot of research went into the development of this product, and each ingredient targets a specific aspect of joint health.

In this article, we will be reviewing the ingredients of Healthmasters’ Joint Rebuilding Formula and their effectiveness according to published, scientific studies. This is not an exhaustive list of the science that went into developing this product but rather a mere snapshot so that you can become familiar.

Here we go.*

Vitamin C

Collagen is a necessary part of the joint and helps to maintain the integrity of cartilage, and several studies support its role in relieving joint pain. Studies have shown that as people age, the amount of collagen in their body decreases, which can lead to increase risks of osteoarthritis [1]. Vitamin C is critical for the body’s synthesis of hyaluronic acid, which helps to improve recovery time and to relieve joint pain. A 2014 study suggests hyaluronic acid can help increase collagen production in the body [2]. Additional studies also support vitamin C’s role in collagen production [3] [4] [5].

Also, vitamin C supplementation has been shown to have anti-inflammatory effects, which can benefit people with joint problems [6] [7] [8] [9] [10]. In one study, researchers found low vitamin C values were linked with decreased physical performance and increased oxidative stress [7].

To summarize, vitamin C was included in the formulation because of its role in collagen production and its anti-inflammatory effects.

Vitamin E

Like vitamin C, vitamin E has anti-inflammatory, as well as antioxidant, properties, which are beneficial for people with joint issues.

A 2013 study found vitamin E to have an anti-inflammatory effect [11], and 2015 study found vitamin E supplementation decreased oxidative stress and supported proper collagen deposition [12].

Further, a 2016 study entitled “Vitamin E slows down the progression of osteoarthritis” found that vitamin E may have a potent therapeutic effect by delaying the progression of osteoarthritis through the maintenance of skeletal muscle [13].

A 2009 investigating the supplementation of vitamin E, fish oil, and nettle found the combination of those supplements to be more effective in improving the symptoms of osteoarthritis than NSAIDs [14].

To summarize, vitamin E was included in the formulation because of its antioxidant and anti-inflammatory properties and its clinical significance with studies supporting its beneficial roles regarding osteoarthritis.

Calcium and Selenium

These two ingredients play a smaller role in this product because of their relatively low doses, but they still promote joint health. Getting enough calcium through diet is essential for the prevention of osteoporosis because of its role in bone and joint health [15].

Several studies have shown that selenium is beneficial for people with rheumatoid arthritis.

A 1997 study found selenium supplementation improves symptoms and has a drug sparing effect in rheumatoid arthritis [16]. At the end of the study, the selenium-supplemented group shows less tender or swollen joints, decreased morning stiffness, and lowered inflammatory markers. Also, the selenium group needed less cortisone and NSAD than the placebo group [16].

Kashin-Beck disease (KBD) is an osteoarthropathy of children and adolescents that occurs in some children. One study found selenium supplementation help children with KBD and decreased their symptoms [17].

A 2007 study investigated the effects of vitamin E and selenium supplementation regarding the regeneration of bone and cartilage defects in animals. The researchers found supplementation of these two vitamins contributed to healing bone and cartilage defects in animals [18].

To summarize, calcium and selenium were included in the formulation because of calcium’s overarching role in joint and bone health and selenium’s clinical significance with helping arthritis and cartilage defects.


Manganese plays a vital role in the development of healthy bone, synthesis of cartilage, and improvement of mineral density [19] [20].

Manganese has also been shown to have an antioxidant effect, as well [21]. This is because manganese is a part of the antioxidant enzyme superoxide dismutase (SOD), which is one of the most important antioxidants in the body [22]. A 2011 study argued manganese supplementation might be essential to prevent diseases in which SOD is an important component [22].

In a 2003 study, researchers found that SOD was less active in people with rheumatoid arthritis, compared to individuals without the condition, which means SOD may have a role in prevention [23].

Further, studies have shown when manganese is taken with glucosamine sulfate and chondroitin sulfate, manganese may help to reduce inflammation.

In a 2000 study, 53% of patients reported, after three months of manganese, glucosamine, and chondroitin supplementation, they had improvements in their osteoarthrosis symptoms [24].

To summarize, manganese was included in the formulation because of its role in cartilage development and its antioxidant effects.

While the above ingredients play active roles in this supplement’s effectiveness, the following five components would be considered the most important.

Omega-3 Fatty Acids with DHA

In my article titled “Fish Oils, Omega-3s, EPA and DHA: A Review of Benefits,” I reviewed omega-3’s beneficial roles regarding various cardiovascular conditions. Yet, there are still many more benefits of DHA, including joint health, which are supported by scientific studies.

A 1990 study found EPA and DHA supplementation may have a therapeutic effect in patients with psoriasis and psoriatic arthritis [25]. The researchers found the majority of patients in the study with psoriatic arthritis reported improvement in their joint pain, with many patients noting complete healing [25].

A 2009 study found omega-3 fatty acids caused a reduction in the mRNA levels for various proteins known to be important in the pathology of osteoarthritis [26]. Based on the results, the researchers suggested omega-3 fatty acid supplementation may be especially useful for supplementation in patients with osteoarthritis [26].

In a 2017 double-blind, placebo-controlled, randomized cross-over study investigating the effects of DHA with rheumatoid arthritis, the researchers found DHA supplementation to improve disease activity in patients with rheumatoid arthritis through various parameters [27].

In 2018, researchers noted that polyunsaturated fatty acids like omega-3 fatty acids decreased osteoarthritis inflammatory markets [28].

In 2010, researchers found krill oil, which is high in EPA and DHA, to be a useful strategy in preventing experimental rheumatoid arthritis [29].

In 2002, after a review of studies, researchers concluded, “Many of the placebo-controlled trials of fish oil in chronic inflammatory diseases reveal significant benefit, including decreased disease activity and a lowered use of anti-inflammatory drugs,” noting omega-3’s strong anti-inflammatory properties [30].

These are only a slim handful of the studies which attest to omega-3’s effectiveness with inflammation and joint health.

To summarize, omega-3 fatty acids with DHA were included in the formulation because of the stark scientific evidence supporting its role regarding joint health.

Hyaluronic Acid

Hyaluronic acid is a naturally occurring compound in synovial fluid, the fluid in joints. Hyaluronic acid helps to create a low-friction environment, cushion joints, and maintain optimal joint function. It also has been shown to have anti-inflammatory and antioxidant properties [31] [32].

Further, a 2008 study showed that supplementation of hyaluronic acid improves symptoms in osteoarthritis of the knee [33].

Though this product offers hyaluronic acid in a powdered substance, researchers have also investigated its effectiveness in shot form.

In 1999, researchers found injections of hyaluronic acid were superior to placebo and well tolerated in patients with osteoarthritis of the knee [34], and a 2003 study found hyaluronic acid injections compare favorably to corticosteroids for the treatment of osteoarthritis of the knee [35].

To summarize, hyaluronic acid was included in the formulation because of its existence in joint synovial fluid, its anti-inflammatory and antioxidant properties, and its clinical effectiveness regarding osteoarthritis.

Glucosamine Sulfate and Chondroitin Sulfate

Glucosamine sulfate is a chondroprotective agent occurring naturally in all human tissues, appears to stimulate the manufacture of cartilage components and the deposition of sulfur into the cartilage. Combined with chondroitin sulfate, glucosamine sulfate may be useful in patients with moderate to severe knee pain [36] [37] [38].

Typically, glucosamine sulfate is extracted from shellfish, but individuals who are allergic to shellfish should not have to be concerned. A 2006 study entitled “Do shrimp-allergic individuals tolerate shrimp-derived glucosamine?” found Glucosamine extracted from shrimp does not demonstrate allergenicity in those allergic to shrimp [39]. However, if you are concerned, consult your doctor and discuss starting with smaller doses.

Chondroitin sulfate is a chemical that is generally found in cartilage around joints in the body and has anti-inflammatory and antioxidant properties [41] [42].

A 2009 study found that a combination of glucosamine, chondroitin, and quercetin significantly improve the symptoms of osteoarthritis and rheumatoid arthritis [40]; 2007 and 2008 reviews came to supplementary conclusions [43] [44].

Concerning a more specific condition, a 2003 study found that the combination of chondroitin sulfate and glucosamine sulfate may treat symptomatic spinal disc degeneration [45].

Interestingly, a 2007 study compared two groups of patients over three years: a placebo group and a glucosamine sulfate group. The researchers found, when compared to the placebo group, glucosamine sulfate significantly decreases the need for total knee replacement in patients with knee osteoarthritis [46].

To summarize, chondroitin sulfate and glucosamine sulfate were included in this product’s formulation because of the numerous clinical studies attesting to its effectiveness with a variety of arthritic conditions.

Methylsulfonylmethane (MSM)

MSM is a natural, sulfur-containing compound that has anti-inflammatory and antioxidant properties, and studies have shown MSM supplementation has therapeutic value in osteoarthritis [47] [48] [53].

A lot of the benefits of MSM are related to exercise recovery, specifically regarding joint pain post-exercise.

A 2006 study investigated MSM’s role in treating osteoarthritis pain after exercise. The researchers found MSM improved symptoms of pain and physical function in those with osteoarthritis [49], and a 2012 study found MSM may favorably influence selected markers of exercise recovery [50].

A 2016 study found that MSM appeared to dampen the release of inflammatory molecules in response to exercise [51], and a 2011 study came to a similar conclusion: Oral supplementation of MSM has alleviating effects on known markers of oxidative stress following acute bouts of exercise in healthy young men [52].

To summarize, MSM was included in this product's formulation because of its effectiveness regarding joint recovery and inflammation.


Alright; so, we have thoroughly examined the ingredients in Healthmasters’ Joint Rebuilding Formula and their benefits backed by published scientific studies. Healthmasters’ Joint Rebuilding Formula supports joint health in a multifaceted amount of ways, supplying antioxidant and anti-inflammatory support, pro-collagen and cartilage ingredients, and other supplements which have been clinically proven to support people who have various arthritic conditions.

If you have any questions about Healthmasters’ Joint Rebuilding Formula, please call our office at 800.726.1834.
























































*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.