Evidence-Based Menopause Support: Dual-Action Support for Hormonal Balance and Symptom Relief

Growing concerns about hot flashes, night sweats, mood variability, deep fatigue, and the emotional heaviness that often accompanies menopause have made women understandably frustrated with the limited natural options available. Many formulas on the market are built around old, under-dosed herbal blends or copied internet folklore rather than research. Healthmasters created Menopause Support and Dimension: Estrogen Control because women deserve evidence-anchored, well-crafted, and biologically meaningful solutions — not guesswork.

Together, these two products form a complementary system that addresses both the symptoms of menopause and the underlying physiological imbalances that drive them. And importantly, the core botanical strategy in Menopause Support now aligns directly with a newly published 2025 randomized, double-blind, placebo-controlled clinical trial, one of the strongest menopause studies to date. This study found that a botanical combination including Black Cohosh, Soy Isoflavones, and SDG Lignans significantly reduced menopausal symptoms across all major categories — somatic, psychological, and urogenital — while showing excellent safety and tolerability [1].

Menopause Support contains the same clinical backbone — Black Cohosh, Isoflavones (from kudzu), Dong Quai, Wild Yam, Licorice Extract, Hesperidin, Ginseng, and Boron — a far more complete matrix than what was studied, but still firmly rooted in the same biological rationale that makes the research so compelling. Dimension: Estrogen Control adds a second pillar by supporting healthy estrogen metabolism through DIM and high-potency curcuminoids, helping smooth out hormonal fluctuations that contribute to irritability, fluid retention, breast tenderness, and estrogen-dominant symptoms.

What the 2025 Study Showed — and Why It Matters

In the published trial, ninety-six women aged forty-five to sixty were followed over a ninety-day period to test whether a botanical blend containing Black Cohosh, Isoflavones, and SDG Lignans could genuinely reduce menopausal symptoms [1]. The researchers used the Menopause Rating Scale (MRS), the gold-standard tool for tracking symptom burden across physical, emotional, and urogenital domains. Women receiving the botanical blend experienced a 44.9% reduction in total symptom burden — nearly cutting their discomfort in half — while the placebo group saw only mild improvement. When directly compared, the active treatment outperformed placebo by 48%, demonstrating true, clinically meaningful relief [1].

Hot flashes, often the most disruptive symptom, decreased by 59.4%, while the placebo group actually worsened by 11.7%.

Psychological symptoms — including irritability, anxiety, and emotional instability — fell by over 50%, with anxiety scores dropping an extraordinary 71%.

Urogenital discomfort also improved significantly more than placebo, demonstrating that the benefits extend beyond surface-level symptom reduction.

The study is powerful not just because of the results, but because the improvements tracked across every major domain of the MRS. This reflects a whole-system influence — supporting neural, hormonal, and metabolic pathways simultaneously — which mirrors the multi-targeted strategy behind Healthmasters’ Menopause Support.

How Menopause Support Works in the Body

Menopause Support is a far more comprehensive formula than the studied blend, but many of its foundational ingredients operate through the same pathways validated by clinical research.

Black Cohosh, the anchor botanical, interacts with serotonin receptors in the hypothalamus — the brain’s command center for temperature and emotional regulation. During menopause, fluctuating estrogen disrupts these pathways, causing the classic hot flash and mood instability cycles. Black Cohosh helps stabilize these signals, promoting calmer thermoregulation and emotional steadiness in a way that is non-hormonal and naturally modulating [1].

Isoflavones in this formula come from kudzu extract, offering a plant-based, receptor-modulating influence similar to the soy-derived isoflavones used in the study. These compounds weakly bind estrogen receptor beta, smoothing hormonal fluctuations and reducing the abrupt physiological swings that intensify symptoms.

Dong Quai (Angelica sinensis), long used in traditional East Asian gynecologic formulas, has been evaluated in randomized trials in postmenopausal women and shows estrogen-related biological activity even though its effect on symptoms alone appears mixed [2].

Wild yam (Dioscorea villosa) is rich in the steroidal saponin diosgenin, a plant steroid widely used as a starting material for pharmaceutical steroid drugs and shown in experimental models to modulate steroid-related signalling pathways [3] [4].

Hesperidin, the citrus bioflavonoid in Menopause Support, has been shown in randomized, double-blind trials to improve endothelial function and cardiovascular biomarkers and to beneficially influence blood pressure and lipids, supporting its role in vascular stability [5] [6].

Korean ginseng (Panax ginseng) has demonstrated cognition-enhancing and fatigue-reducing effects in randomized, placebo-controlled trials, which aligns with its use for daily energy and cognitive resilience [7] [8].

Licorice-derived glycyrrhetinic acid inhibits 11β-hydroxysteroid dehydrogenase and alters cortisol–cortisone balance in humans, illustrating how standardized licorice extracts can influence adrenal tone and stress-hormone handling [9].

Boron, a trace mineral, has been shown in postmenopausal women to increase circulating estradiol and testosterone and reduce urinary calcium loss, supporting a role in estrogen metabolism and bone signaling during and after menopause [10] [11].

Each of these ingredients contributes to a different node in the interconnected network of menopause physiology. When combined, they create a layered, synergistic environment that promotes physical ease, emotional balance, temperature stability, and hormonal rhythm.

Where Dimension: Estrogen Control Fits into the Picture

Dimension: Estrogen Control adds the second half of the equation: estrogen metabolism. Menopause is not simply about estrogen decline — it is also about how estrogen is broken down and cleared. Poor estrogen metabolism can worsen cycles of irritability, fluid retention, breast tenderness, weight redistribution, and the “estrogen dominance” sensation many women describe.

DIM (diindolylmethane) — the centerpiece of Dimension — influences estrogen conversion in the liver, promoting the formation of healthier estrogen metabolites while reducing problematic pathways [12]. This is crucial during menopause, when the ratio of estrogen metabolites can shift unfavorably. DIM helps restore a more beneficial biochemical profile, offering smoother mood, reduced hormonal tension, and improved breast and pelvic comfort [12].

The addition of high-potency curcuminoids (95% curcuminoids) amplifies this effect through antioxidant and anti-inflammatory pathways [13] [14]. Curcumin also enhances cellular signaling involved in hormonal detoxification and supports the stability of tissues that rely on estrogen for normal function.

Black Pepper Extract ensures enhanced absorption, allowing both DIM and curcuminoids to reach effective levels more reliably [15].

Together, Menopause Support and Dimension: Estrogen Control create a complementary pairing: one formula supports symptom relief and neurological stability, while the other supports hormonal processing and metabolic balance.

How These Two Products Work Together

When taken together, these formulas offer a dual-action approach aligned with the complex nature of menopause. Menopause Support can help stabilize the systems responsible for temperature control, sleep quality, emotional steadiness, and physical comfort. Dimension: Estrogen Control help support hormonal metabolites to shift toward a healthier, more favorable profile, which may reduces irritability, breast tenderness, and estrogen-dominant tension.

The two formulas do not compete with one another — they support different phases of the same hormonal cycle, which is why combining them produces a smoother, more comprehensive improvement than either could offer alone.

Conclusion

The newly published 2025 clinical trial offers some of the strongest evidence yet that a botanical blend centered around Black Cohosh, Isoflavones, and Lignans can significantly reduce menopausal symptoms across all major domains. Healthmasters’ Menopause Support formula is built upon this same foundational science, while adding botanicals and nutrients that reinforce hormonal comfort, stress resilience, and emotional balance. Healthmasters’ Dimension: Estrogen Control complements this by supporting the metabolic side of estrogen regulation, offering smoother hormonal transitions and improved comfort during a phase of life known for its unpredictability.

For women seeking a natural, non-hormonal system to move through menopause with steadiness, clarity, and comfort, these two Healthmasters products help support a scientifically grounded, physiologically complete solution.

(If you are taking any hormone-replacement therapy products prescribed by your physician, consult with them prior to you beginning Healthmasters’ Menopause Support or Dimension: Estrogen Control.)

Reference

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[2] Hirata, J. D., Swiersz, L. M., Zell, B., Small, R., & Ettinger, B. (1997). Does dong quai have estrogenic effects in postmenopausal women? A double-blind, randomized, placebo-controlled trial. Fertility and Sterility, 68(6), 981–986. https://doi.org/10.1016/S0015-0282(97)00397-X

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[11] Rondanelli, M., Faliva, M. A., Peroni, G., Infantino, V., Gasparri, C., Iannello, G., Perna, S., Riva, A., Petrangolini, G., & Tartara, A. (2020). Pivotal role of boron supplementation on bone health: A narrative review. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 62, 126577. https://doi.org/10.1016/j.jtemb.2020.126577

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*The matters discussed in this article are for informational purposes only and not medical advice. Please consult your healthcare practitioner on the matters discussed herein.

*These statements have not been evaluated by the Food and Drug Administration. Healthmasters' products are not intended to diagnose, treat, cure, or prevent any disease.