Berberine Ultimate features dihydroberberine (DHB), a highly bioavailable metabolite of berberine with 5-times the bioavailability of standard berberine . Berberine naturally occurs in several plant species used extensively in traditional Ayurvedic and Chinese herbal practices.
- Blood sugar support
- Supports enhanced berberine activity
- Supports healthy blood glucose metabolism
- Supports reduced inflammation and gout production
- Supports healthy cholesterol and weight levels
- Third-Party GMP Compliant Verified
Dihydroberberine vs. Berberine
Dihydroberberine (DHB) is a compound similar to berberine (BBR), a well-known anti-inflammatory compound found in several plants. The primary difference between dihydroberberine and berberine is the presence of an additional hydrogen atom in DHB's structure. This small difference in structure results in several differences in their properties:
1. Dihydroberberine has been shown to have higher bioavailability and absorption in the body compared to berberine   . This means that it can be more effective at lower doses and may have a longer-lasting effect.
2. Dihydroberberine is more stable than berberine, meaning it is less likely to break down in the body or during processing and storage. This increased stability can lead to a longer shelf-life and better overall quality of the product.
3. Some studies suggest that dihydroberberine may have a milder effect on certain enzymes and receptors in the body compared to berberine. This could make it a better option for people who experience side effects from berberine or who need a gentler treatment.
Overall, while both dihydroberberine and berberine are structurally similar and have similar health benefits, dihydroberberine is a more effective and tolerable option, making it the Ultimate Berberine.
Potential Research-Backed Benefits
Researchers found DHB in a Chinese plant and wanted to investigate its anti-inflammatory effects. They tested the compound in three types of inflammation in mice and found that DHB reduced inflammation in all three cases and decreased the levels of inflammation-related molecules in the body. These findings could help explain why the Chinese plant is used in traditional medicine to treat inflammatory diseases .
In a 2008 study, researchers found that BBR lowered blood sugar levels just as well as metformin in three months, along with the patients' fasting blood glucose and after-meal blood glucose. The study also found that after one week, berberine lowered fasting and post-meal blood glucose levels and decreased insulin resistance by an average of 45% .
In a 2012 meta-analysis, researchers evaluated fourteen randomized trials that included 1,068 participants and found that BBR appeared to be efficacious for treating hyperglycemia and dyslipidemia in type-2 diabetes. BBR performed similarly to metformin, glipizide, and rosiglitazone, without any severe side effects .
In another study, researchers investigated the effect of DHB on mice with high levels of uric acid in their blood. They found that DHB lowered the levels of uric acid in the blood and improved kidney function. DHB could inhibit the activity of an enzyme called xanthine oxidase, which is involved in the production of uric acid in the body. DHB also had anti-inflammatory effects on the kidney and reduced the expression of genes associated with inflammation, suggesting that DHB could be a potential treatment for hyperuricemia and gout .
Another study looked at whether BBR could help with obesity and high cholesterol levels. Obese human subjects were given 500 mg of BBR three times a day for twelve weeks. The study found that berberine treatment produced a mild weight loss and significantly reduced blood lipid levels. BBR treatment also showed a lipid-lowering effect in a rat experiment. Tests of hematological, cardiovascular, liver, and kidney function following berberine treatment showed no detrimental side effects to this natural compound. This study suggests that BBR could be a potential natural treatment for high cholesterol levels and obesity .