Sublingual B12 (Methylcobalamin)

Product Rating: 
sublingual b12
SKU: 4172


Applications for Health Improvement​

  • Supports healthy methylation
  • Supports neurological health
  • Supports red blood cell formation
  • Supports healthy sleep patterns
  • Supports a healthy immune system
  • Increases energy levels


60 Great Tasting, Natural Orange Flavor & Quick-Dissolve Tablets

5000 mcg/tablet

Vitamin B12 can be obtained through its synthesis by intestinal flora, from animal-based or fortified foods, or from supplementation. Unlike most other water-soluble vitamins, vitamin B12 (4 to 6 mg) is bound to a protein and stored in the liver as methylcobalamin or 5’-deoxyadenosylcobalamin. These are the coenzyme forms of B12 that are active in human metabolism. Reserve stores of B12 can become depleted due to poor dietary intake without supplementation or poor intestinal absorption.

Many vitamin B12 supplements on the market contain cyanocobalamin. The liver is only able to convert a small amount of cyanocobalamin to methylcobalamin. Methylcobalamin is the preferred form since it is the bioactive form and therefore better utilized. Tissue retention of cobalamin was greater when using the methyl- form versus the cyano- form. This was exemplified by the fact that urinary excretion of methylcobalamin was one-third less that of cyanocobalamin [1]. Another point of interest regarding B12 supplementation is the commonly held belief that intramuscular injections of B12 are more effective than oral supplementation. In fact, oral supplementation is just as effective and carries the added benefits of lower cost and ease of administration [2,3].

Our formula uses MecobalActive™, which is a pure form of methylcobalamin. Unlike other sources of methylcobalamin on the market, MecobalActive™ does not use any harmful solvents during its manufacture. The patented, advanced production methods used to create MecobalActive™ also result in a methylcobalamin with greater purity and lower moisture, which translates to greater stability. 

Methylation: Methylcobalamin is required for the function of methionine synthase—the folate-dependent enzyme required for the synthesis of methionine, an amino acid, from homocysteine. Methionine, in turn, is required for the synthesis of S-adenosylmethionine (SAMe), a methyl group donor used in many biological methylation reactions, including the methylation of a number of sites within DNA and RNA.

Neurologic Health: Methylcobalamin is necessary for the maintenance of a healthy nervous system. Chronic insufficiency can affect the spinal cord, peripheral nerves, optic nerve, and brain. This can be explained by methylcobalamin’s role as a cofactor in myelin synthesis; in methylation of the toxic byproduct homocysteine, which is thought to damage neurons; and in the synthesis of monoamine neurotransmitters, such as serotonin, dopamine, and norepinephrine [4-6].

Red Blood Cell Formation: Like folate, red blood cells require vitamin B12 for proliferation during their differentiation.

Sleep Support: Methylcobalamin has been reported to affect the primary circadian rhythm associated with sleep [7,8]. Supplementation supports modulating melatonin secretion, enhancing light-sensitivity, normalizing circadian rhythms, and improving sleep-wake cycles [9-11].


  1. Methylcobalamin. Altern Med Rev. 1998 Dec;3(6):461-3. Erratum in: Altern Med Rev 1999 Feb;4(1):9. [PMID: 9855571]
  2. Kuzminski AM, Del Giacco EJ, Allen RH, et al. Effective treatment of cobalamin deficiency with oral cobalamin. Blood. 1998 Aug 15;92(4):1191-98. [PMID: 9694707]
  3. Kim HI, Hyung WJ, Song KJ, et al. Oral vitamin B12 replacement: an effective treatment for vitamin B12 deficiency after total gastrectomy in gastric cancer patients. Ann Surg Oncol. 2011 Dec;18(13):3711-17. [PMID: 21556950]
  4. Puri V, Chaudhry N, Goel S, et al. Vitamin B12 deficiency: a clinical and electrophysiological profile. Electromyogr Clin Neurophysiol. 2005 JulAug;45(5):273-84. [PMID: 16218195]
  5. Hemendinger RA, Armstrong EJ 3rd, Brooks BR. Methyl Vitamin B12 but not methylfolate rescues a motor neuron-like cell line from homocysteine-mediated cell death. Toxicol Appl Pharmacol. 2011 Mar 15;251(3):217-25. [PMID: 21237187]
  6. Valizadeh M, Valizadeh N. Obsessive compulsive disorder as early manifestation of B12 deficiency. Indian J Psychol Med. 2011 Jul;33(2):203-04. [PMID: 22345852]
  7. Mayer G, Kröger M, Meier-Ewert K. Effects of vitamin B12 on performance and circadian rhythm in normal subjects. Neuropsychopharmacology. 1996 Nov;15(5):456-64. [PMID: 8914118]
  8. Yamadera W, Sasaki M, Itoh H, et al. Clinical features of circadian rhythm sleep disorders in outpatients. Psychiatry Clin Neurosci. 1998 Jun;52(3):311-16. [PMID: 9681583]
  9. Kiuchi T, Sei H, Seno H, et al. Effect of vitamin B12 on the sleep-wake rhythm following an 8-hour advance of the light-dark cycle in the rat. Physiol Behav. 1997 Apr;61(4):551-54. [PMID: 9108574]
  10. Honma K, Kohsaka M, Fukuda N, et al. Effects of vitamin B12 on plasma melatonin rhythm in humans: increased light sensitivity phase-advances the circadian clock? Experientia. 1992 Aug 15;48(8):716-20. [PMID: 1516676]
  11. Tamura J, Kubota K, Murakami H, et al. Immunomodulation by vitamin B12: augmentation of CD8+ T lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl-B12 treatment. Clin Exp Immunol. 1999 Apr;116(1):28-32. [PMID: 10209501]
Vitamin B