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Applications for Health Improvement
- Supports healthy thyroid function
- Supports the body's conversion of T4 to the more active hormone T3
- Excellent for those with either hyper or hypothyroidism
120 Vegetarian Capsules
This formula provides targeted nutrients and herbs that support healthy thyroid hormone biosynthesis. This combination may facilitate the expression of thyroid hormone genes. The addition of ashwagandha and guggul extract may aid in the conversion of thyroxine to triiodothyronine (T4 to T3) and may assist in maintaining healthy blood lipid levels already within the normal range.
Iodine: The thyroid gland produces two main iodine-containing hormones: thyroxine (T4) and triiodothyronine (T3). These hormones circulate in the bloodstream and work on every living tissue and cell to regulate metabolism and growth. Of the body’s iodine pool (about 15 mgs in adults), 80% is contained in the thyroid gland. Iodine is primarily used as a substrate for the manufacture of T4 and T3, and healthy iodine status is imperative for normal thyroid function and thyroid hormone biosynthesis [1,2].
Selenium: Is an essential component of many selenoproteins that regulate thyroid hormone synthesis, preserve thyroid integrity in conditions of marked oxidative stress, and control hormone metabolism in nonthyroidal tissues where the prohormone T4 is converted to biologically active T3 or its inactive isomer rT3 .
Zinc and Vitamins A and D: Research suggests that inadequate intakes of zinc and vitamins A and D may impact thyroid hormone metabolism, circulating thyroid hormone concentrations, the thyroid’s response to iodine prophylaxis, and antithyroid antibody levels [2,3-5].
Retinyl palmitate is used in this formula rather than beta-carotene because certain individuals may lack the ability to effectively convert beta-carotene or other carotenoids into vitamin A.  It is also important to note that vitamin D facilitates intestinal calcium absorption and therefore helps maintain the ratio of calcium to phosphorous, which can be affected by low thyroid function and certain thyroid therapies.
Vitamin E and Rosemary: Studies support the concept of reducing oxidative stress in order to protect thyroid cell health and maintain normal thyroid cell growth and lifecycle . Active oxygen radicals can inhibit the activity of an enzyme involved in the conversion of T4 to T3, reducing oxidative stress may have a two-fold application in thyroid health . Antioxidative components, such as vitamin E and rosemary, may help protect thyroid cells/tissue and also support the enzymatic conversion of T4 to T3 by scavenging damaging free radicals [7,8].
Guggulsterones and Ashwagandha: Researchers have demonstrated the positive influence guggul extract can have on thyroid function and blood lipid metabolism [9,10].
CAUTIONS: Do not take if you are pregnant or lactating. Excess vitamin A intake may be toxic and may increase the risk of birth defects. Pregnant women and women who might become pregnant should not exceed 5000 IU of preformed vitamin A (retinyl palmitate) per day.
- Mansourian AR. A review on the metabolic disorders of iodine deficiency. Pak J Biol Sci. 2011 Apr 1;14(7):412-24. [PMID: 21902053]
- Arthur JR, Beckett GJ. Thyroid function. Br Med Bull. 1999;55(3):658-68. [PMID: 10746354]
- Zimmermann MB. Interactions of vitamin A and iodine deficiencies: effects on the pituitary-thyroid axis. Int J Vitam Nutr Res. 2007 May;77(3):236-40. [PMID: 18214025]
- Ertek S, Cicero AF, Caglar O, et al. Relationship between serum zinc levels, thyroid hormones and thyroid volume following successful iodine supplementation. Hormones (Athens). 2010;9(3):263-68. [PMID: 20688624]
- Kivity S, Agmon-Levin N, Zisappl M, et al. Vitamin D and autoimmune thyroid diseases. Cell Mol Immunol. 2011;8(3):243-47. [PMID: 21278761]
- Xing M. Oxidative stress: a new risk factor for thyroid cancer. Endocr Relat Cancer. 2012 Jan 9;19(1):C7-11. [PMID: 22143496]
- Brzezinska-Slebodzinska E, Pietras B. The protective role of some antioxidants and scavengers on the free radicals-induced inhibition of the liver iodothyronine 5’-monodeiodinase activity and thiols content. J Physiol Pharmacol. 1997 Sep;48(3):451-59. [PMID: 9376628]
- Mano T, Iwase K, Hayashi R, et al. Vitamin E and coenzyme Q concentrations in the thyroid tissues of patients with various thyroid disorders. Am J Med Sci. 1998 Apr;315(4):230-32. [PMID: 9537635]
- Panda S, Kar A. Guggulu (Commiphora mukul) potentially ameliorates hypothyroidism in female mice. Phytother Res. 2005 Jan;19(1):78-80. [PMID: 15798994]
- Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. J Ethnopharmacol. 1999;67(2):233-39. [PMID: 10619390]
Serving Size: 2 Capsules